Noonan C

Moudon AV, Huang R, Stewart OT, Cohen-Cline H, Noonan C, Hurvitz PM, Duncan GE. Background Individual sociodemographic and home neighborhood built environment (BE) factors influence the probability of engaging in health-enhancing levels of walking or moderate-to-vigorous physical activity (MVPA). Methods are needed to parsimoniously model the associations. Methods Participants included 2392 adults drawn from a […]

Watson NF, Buchwald D, Delrow JJ, Altemeier WA, Vitiello MV, Pack AI, Bamshad M, Noonan C, Gharib S. Habitual short sleep duration is associated with adverse metabolic, cardiovascular, and inflammatory effects. Co-twin study methodologies account for familial (e.g., genetics and shared environmental) confounding, allowing assessment of subtle environmental effects, such as the effect of habitual […]

Melhorn SJ, Mehta S, Kratz M, Tyagi V, Webb MF, Noonan CJ, Buchwald DS, Goldberg J, Maravilla KR, Grabowski TJ, Schur EA Background Neural responses to highly energetic food cues are robust and are suppressed by eating. It is not known if neural responsiveness to food cues is an inherited trait and possibly even one […]

Wrede JE, Mengel-From J, Buchwald D, Vitiello MV, Bamshad M, Noonan C, Christiansen L, Christensen K, Watson NF Mitochondrial DNA (mtDNA) copy number is an important component of mitochondrial function and varies with age, disease, and environmental factors. We aimed to determine whether mtDNA copy number varies with habitual differences in sleep duration within pairs […]

Godfrey KM, Strachan E, Dansie E, Crofford LJ, Buchwald D, Goldberg J, Poeschla B, Succop A, Noonan C, Afari N There is a dearth of knowledge about the link between cortisol and pain sensitivity. We examined the association of salivary cortisol with indices of cold pain sensitivity in 198 female twins and explored the role of […]

Holley AL, Law EF, Tham SW, Myaing M, Noonan C, Strachan E, Palermo TM Chronic pain is common during adolescence and young adulthood and is associated with poor quality of life, depression, and functional disability. Recognizing that chronic pain has significant consequences, it is important to identify modifiable health behaviors that may place young adults […]

Strachan E, Hunt C, Afari N, Duncan G, Noonan C, Schur E, Watson N, Goldberg J, Buchwald D The University of Washington Twin Registry is a unique community-based registry of twin pairs who join specifically to participate in scientific research. It was founded in 2002 to serve as a resource for investigators throughout the scientific […]

Plesh O, Noonan C, Buchwald DS, Goldberg J, Afari N To determine whether shared genetic influences are responsible for the association between pain from temporomandibular disorders (TMD) and migraine headache. Data were obtained from 1,236 monozygotic and 570 dizygotic female twin pairs from the University of Washington Twin Registry. TMD pain was assessed with a question […]

Watson NF, Buchwald D, Noonan C, Vitiello MV, Pack AI, Goldberg J We used the community-based University of Washington Twin Registry to investigate the genetic association between circadian type and sleep duration. Habitual sleep duration was obtained by self-report and circadian type was measured using a reduced 5-item Horne–Östberg Morningness–Eveningness questionnaire. Univariate and bivariate genetic […]

Afari N, Mostoufi S, Noonan C, Poeschla B, Succop A, Chopko L, Strachan E Systemic inflammation and pain sensitivity may contribute to the development and maintenance of chronic pain conditions. We examined the relationship between systemic inflammation as measured by C-reactive protein (CRP) and cold pain sensitivity in 198 female twins from the University of Washington […]

Afari N, Noonan C, Goldberg J, Roy-Byrne P, Schur E, Golnari G, Buchwald D Studies have found a modest association between depression and obesity, especially in women. Given the substantial genetic contribution to both depression and obesity, we sought to determine whether shared genetic influences are responsible for the association between these 2 conditions. Data were […]

Wright LJ, Schur E, Noonan C, Ahumada S, Buchwald D, Afari N Chronic pain and obesity, and their associated impairments, are major health concerns. We estimated the association of overweight and obesity with 5 distinct pain conditions and 3 pain symptoms, and examined whether familial influences explained these relationships. We used data collected from 3,471 twins […]

Schur E, Noonan C, Polivy J, Goldberg J, Buchwald D We examined the relative contributions of genetic and environmental influences to restrained eating. Restrained eating was assessed by the Restraint Scale in a survey mailed to all twins enrolled in the University of Washington Twin Registry. We used structural equation modeling to estimate genetic and non-genetic […]

Schur E, Noonan C, Buchwald D, Goldberg J, Afari N To determine if shared genetic or environmental vulnerabilities could underlie depression and migraine. Depression and migraine headaches frequently coexist and their comorbidity may be due to shared etiologies. Female twins in the University of Washington Twin Registry responded to a mailed survey regarding their health history. Depression […]

Duncan GE, Goldberg J, Noonan C, Moudon AV, Hurvitz P, Buchwald D The health benefits of regular physical activity are well established. However, the relative contribution of heritable and environmental factors to physical activity participation remains controversial. Using a cut-point of 60 minutes of total activity per week, data from the GenomEUtwin project revealed consistent […]

Afari N, Noonan C, Goldberg J, Edwards K, Gadepalli K, Osterman B, Evanoff C, Buchwald D The University of Washington Twin Registry is a community-based registry of twins identified from the Washington State Department of Licensing. A fortuitous quirk in the Washington State drivers’ license and identification number assignment, and collaborative Washington State laws, permitted […]

Roy-Byrne P, Noonan C, Afari N, Buchwald D, Goldberg J The objective of this study was to identify genetic, familial and environmental contributions to the association between posttraumatic stress disorder (PTSD) symptoms and poor health. A community sample of 1852 twin pairs was assessed for symptoms of PTSD [with the Impact of Events Scale (IES)] and […]