Roy-Byrne P

Genome-wide profiling of DNA methylome and transcriptome in peripheral blood monocytes for major depression: A Monozygotic Discordant Twin Study

Zhu Y, Strachan E, Fowler E, Bacus T, Roy-Byrne P, Zhao J. DNA methylation plays an important role in major depressive disorder (MDD), but the specific genes and genomic regions associated with MDD remain largely unknown. Here we conducted genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) and gene expression (RNA-seq) in peripheral blood monocytes […]

Study Design and Rationale for the Mood and Methylation Study: A Platform for Multi-Omics Investigation of Depression in Twins

Strachan E, Zhao J, Roy-Byrne PP, Fowler E, Bacus T. Major depression is a complex disorder with no single, direct causal mechanism. Morbidity has been linked to genetic processes, developmental history, and unique environmental exposures. Epigenetic mechanisms, especially DNA methylation, are also likely important factors in the pathogenesis of major depressive disorder (MDD). A community-based […]

Childhood Trauma, DNA Methylation of Stress-related Genes, and Depression: Findings from Two Monozygotic Twin Studies

Peng H, Zhu Y, Strachan E, Fowler E, Bacus T, Roy-Byrne P, Goldberg J, Vaccarino V, Zhao J. Objective DNA methylation has been associated with both early life stress and depression. This study examined the combined association of DNA methylation at multiple CpG probes in five stress-related genes with depressive symptoms, and tested whether these […]

Depression and obesity: Do shared genes explain the relationship?

Afari N, Noonan C, Goldberg J, Roy-Byrne P, Schur E, Golnari G, Buchwald D Studies have found a modest association between depression and obesity, especially in women. Given the substantial genetic contribution to both depression and obesity, we sought to determine whether shared genetic influences are responsible for the association between these 2 conditions. Data were […]

Is the association between posttraumatic stress disorder symptoms and poor health due to a common familial or genetic factor?

Roy-Byrne P, Noonan C, Afari N, Buchwald D, Goldberg J The objective of this study was to identify genetic, familial and environmental contributions to the association between posttraumatic stress disorder (PTSD) symptoms and poor health. A community sample of 1852 twin pairs was assessed for symptoms of PTSD [with the Impact of Events Scale (IES)] and […]