Godfrey KM, Herbert M, Strachan E, Mostoufi S, Crofford LJ, Buchwald D, Poeschla B, Succop A, Afari N. Objectives Hypothalamic-pituitary-adrenal (HPA) axis dysregulation is associated with chronic pain. Studying pain sensitivity and the HPA axis could elucidate the role of stress in chronic pain development, which might be influenced by familial factors, including genes. Methods […]
Godfrey KM, Strachan E, Mostoufi S, Poeschla B, Succop A, Afari N The relationship between sleep quality and pain has been studied in populations with chronic pain and in nonclinical populations using experimental paradigms. Little is known about the familial contributions to this relationship. This study examines self-reported sleep quality and pain in a nonclinical […]
Strachan E, Poeschla B, Dansie E, Succop A, Chopko L, Afari N Pain is a complex phenomenon influenced by context and person-specific factors. Affective dimensions of pain involve both enduring personality traits and fleeting emotional states. We examined how personality traits and emotional states are linked with clinical and evoked pain in a twin sample. 99 […]
Godfrey KM, Strachan E, Dansie E, Crofford LJ, Buchwald D, Goldberg J, Poeschla B, Succop A, Noonan C, Afari N There is a dearth of knowledge about the link between cortisol and pain sensitivity. We examined the association of salivary cortisol with indices of cold pain sensitivity in 198 female twins and explored the role of […]
PI: Brian PoeschlaProject Number: 5R03NR012841Project Dates: 2/15/2012–7/31/2014 Both acute and persistent pains are major public health concerns yet causes and prognoses are poorly understood. In addition to basic pain stimulus perception (i.e. nociception) genetic, endocrine, immunologic and nutritional factors are hypothesized to contribute. Women may be especially at risk. One putative risk factor is vitamin D […]
Afari N, Mostoufi S, Noonan C, Poeschla B, Succop A, Chopko L, Strachan E Systemic inflammation and pain sensitivity may contribute to the development and maintenance of chronic pain conditions. We examined the relationship between systemic inflammation as measured by C-reactive protein (CRP) and cold pain sensitivity in 198 female twins from the University of Washington […]
