Sewaybricker LE, Melhorn SJ, Rosenbaum JL, Askren MK, Tyagi V, Webb MF, De Leon MRB, Grabowski TJ, Schur EA Background Neuroimaging studies suggest that appetitive drive is enhanced in obesity. Objective To test if appetitive drive varies in direct proportion to the level of body adiposity after accounting for genetic factors that contribute to both […]
Sewaybricker LE, Melhorn SJ, Askren MK, Webb MF, Tyagi V, De Leon MRB, Grabowski TJ, Seeley WW, Schur EA. BACKGROUND/OBJECTIVES The salience network (SN) comprises brain regions that evaluate cues in the external environment in light of internal signals. We examined the SN response to meal intake and potential genetic and acquired influences on SN […]
Berkseth KE, Rubinow KB, Melhorn SJ, Webb MF, De Leon MRB, Marck BT, Matsumoto AM, Amory JK, Page ST, Schur EA. Objective This study aimed to determine whether a relationship was evident between gliosis in the mediobasal hypothalamus (MBH) and plasma testosterone concentrations in men. Methods A total of 41 adult men (aged 18-50 years) […]
Melhorn SJ, Askren MK, Chung WK, Kratz M, Bosch TA, Tyagi V, Webb MF, De Leon MRB, Grabowski TJ, Leibel RL, Schur EA. Background Variants in the first intron of the fat mass and obesity-associated (FTO) gene increase obesity risk. People with “high-risk” FTO genotypes exhibit preference for high-fat foods, reduced satiety responsiveness, and greater […]
Schur E, Carnell S. Purpose of Review Functional magnetic resonance imaging (fMRI) using visual food cues provides insight into brain regulation of appetite in humans. This review sought evidence for genetic determinants of these responses. Recent Findings Echoing behavioral studies of food cue responsiveness, twin study approaches detect significant inherited influences on brain response to […]
Mestre ZL, Melhorn SJ, Askren MK, Tyagi V, Gatenby C, Young L, Mehta S, Webb MF, Grabowski TJ, Schur EA. Objective To test the relationship of anxiety to caloric intake and food cue perception in women and men. Methods Fifty-five twins (26 complete, 3 incomplete pairs; 51% women) underwent 2 functional magnetic resonance imaging (fMRI) […]
Melhorn SJ, Mehta S, Kratz M, Tyagi V, Webb MF, Noonan CJ, Buchwald DS, Goldberg J, Maravilla KR, Grabowski TJ, Schur EA Background Neural responses to highly energetic food cues are robust and are suppressed by eating. It is not known if neural responsiveness to food cues is an inherited trait and possibly even one […]
Bosch TA, Chow L, Dengel DR, Melhorn SJ, Webb M, Yancey D, Callahan H, De Leon MRB, Tyagi V, Schur EA We recently reported sex-specific percent body fat (%BF) thresholds (males = 23%, females = 38%) above which, visceral adipose tissue (VAT) significantly increases. Using monozygotic (MZ) and dizygotic (DZ) twins, we examined the influence of genetics on regional […]
