Duncan GE

Neighborhood Deprivation Moderates Shared and Unique Environmental Influences on Hazardous Drinking: Findings from a Cross-Sectional Co-Twin Study

Rhew IC, Fleming CB, Tsang S, Horn E, Kosterman R, Duncan GE. Background There has been increased interest in the interplay of genetic and environmental factors in the development of problematic alcohol use, including socioeconomic conditions of the neighborhood. Using a co-twin design, we examined the extent to which contributions of genetic, shared environmental, and […]

Cohort Profile: TWINS study of environment, lifestyle behaviours and health

Duncan GE, Avery A, Hurvitz PM, Moudon AV, Tsang S, Turkheimer E. The role of built and social environments in supporting healthy lifestyles has received increased attention over the past decade, as research and prevention paradigms have shifted from a focus on individual-level behaviour change to macro-level influences embedded within social-ecological models of health that […]

Sleep Duration and Post-Traumatic Stress Disorder Symptoms: A Twin Study

McCall CA, Turkheimer E, Tsang S, Avery A, Duncan GE, Watson NF. Study Objectives Long and short sleep duration are associated with greater risk of developing post-traumatic stress disorder (PTSD); however, it is unknown how genetic and environmental influences impact this relationship. Thus, we investigated the association between sleep duration and PTSD symptoms using twin […]

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

Silventoinen K, Jelenkovic A, Yokoyama Y, Sund R, Sugawara M, Tanaka M, Matsumoto S, Bogl LH, Freitas DL, Maia JA, Hjelmborg JVB, Aaltonen S, Piirtola M, Latvala A, Calais-Ferreira L, Oliveira VC, Ferreira PH, Ji F, Ning F, Pang Z, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Burt SA, Klump KL, Martin NG, Medland SE, Montgomery […]

The Washington State Twin Registry: 2019 Update

Duncan GE, Avery AR, Strachan E, Turkheimer E, Tsang S. It has been over 5 years since the last special issue of Twin Research and Human Genetics on ‘Twin Registries Worldwide: An Important Resource for Scientific Research’ was published. Much progress has been made in the broad field of twin research since that time, and the current […]

Probabilistic walking models using built environment and sociodemographic predictors

Moudon AV, Huang R, Stewart OT, Cohen-Cline H, Noonan C, Hurvitz PM, Duncan GE. Background Individual sociodemographic and home neighborhood built environment (BE) factors influence the probability of engaging in health-enhancing levels of walking or moderate-to-vigorous physical activity (MVPA). Methods are needed to parsimoniously model the associations. Methods Participants included 2392 adults drawn from a […]

Heritability of Type 2 Diabetes in the Washington State Twin Registry

Avery AR, Duncan GE Approximately 12% of U.S. adults have type 2 diabetes (T2D). Diagnosed T2D is caused by a combination of genetic and environmental factors including age and lifestyle. In adults 45 years and older, the Discordant Twin (DISCOTWIN) consortium of twin registries from Europe and Australia showed a moderate-to-high contribution of genetic factors […]

A twin study of genetic influences on nephrolithiasis in women and men

Goldfarb DS, Avery AR, Beara-Lasic L, Duncan GE, Goldberg J. Background Nephrolithiasis is a complex phenotype influenced by both genetic and environmental factors. Previously we found a genetic component to stone disease using a sample of male twin pairs. We now report on the genetic contribution to stones in a sample of female and male […]

Familial factors predicting recovery and maintenance of physical activity in people with low back pain: insights from a population-based twin study

Zadro JR, Shirley D, Duncan GE, Ferreira PH. BACKGROUND It is unknown how familial factors influence the recovery from low back pain (LBP) and the maintenance activity behaviours. We aimed to investigate whether individual and within-family physical activity (PA) and sedentary behaviour influenced recovery from LBP, and maintenance of PA and sedentary behaviour in people […]

Usability of a Personal Air Pollution Monitor: Design-Feedback Iterative Cycle Study

Duncan GE, Seto E, Avery AR, Oie M, Carvlin G, Austin E, Shirai JH, He J, Ockerman B, Novosselov I. Background There is considerable evidence that exposure to fine particulate matter (PM2.5) air pollution is associated with a variety of adverse health outcomes. However, true exposure-outcome associations are hampered by measurement issues, including compliance and […]

DNA methylation associated with healthy aging of elderly twins

Kim S, Wyckoff J, Morris AT, Succop A, Avery A, Duncan GE, Michal Jazwinski S. Variation in healthy aging and lifespan is ascribed more to various non-genetic factors than to inherited genetic determinants, and a major goal in aging research is to reveal the epigenetic basis of aging. One approach to this goal is to […]

Using Smart City Technology to Make Healthcare Smarter

Cook DJ, Duncan G, Sprint G, Fritz R. Smart cities use information and communication technologies (ICT) to scale services include utilities and transportation to a growing population. In this article we discuss how smart city ICT can also improve healthcare effectiveness and lower healthcare cost for smart city residents. We survey current literature and introduce […]

Differential models of twin correlations in skew for body-mass index (BMI)

Tsang S, Duncan GE, Dinescu D, Turkheimer E. Background Body Mass Index (BMI), like most human phenotypes, is substantially heritable. However, BMI is not normally distributed; the skew appears to be structural, and increases as a function of age. Moreover, twin correlations for BMI commonly violate the assumptions of the most common variety of the […]

Associations between social capital and depression: A study of adult twins

Cohen-Cline H, Beresford SA, Barrington W, Matsueda R, Wakefield J, Duncan GE. Social capital is associated with depression independently of individual-level risk factors. We used a sample of 1586 same-sex twin pairs to test the association between seven measures of social capital and two related measures of neighborhood characteristics with depressive symptoms accounting for uncontrolled […]

Associations between neighbourhood characteristics and depression: a twin study

Cohen-Cline H, Beresford SAA, Barrington WE, Matsueda RL, Wakefield J, Duncan GE. Background Depression is an important contributor to the global burden of disease. Besides several known individual-level factors that contribute to depression, there is a growing recognition that neighbourhood environment can also profoundly affect mental health. This study assessed associations between three neighbourhood constructs-socioeconomic […]

Examination of Cross-Sectional Associations of Neighborhood Deprivation and Alcohol Outlet Density With Hazardous Drinking Using a Twin Design

Rhew IC, Kosterman R, Duncan GE, Mair C. Objective The purpose of this study was to examine whether neighborhood socioeconomic deprivation and alcohol outlet density are associated with hazardous drinking using a co-twin design to control for confounding because of genetic and shared environmental factors. Method The study sample included cross-sectional data from 1,996 same-sex […]

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts

Silventoinen K, Jelenkovic A, Hopper JL, Busjahn A, Cozen W, Mack TM, Sumathipala A, Harris JR, Goldberg JH, Harden KP, Duncan GE, Buchwald D, Turkheimer E, Kaprio J, et al. Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences […]

TWINStudy of Environment, Lifestyle Behaviors, and Health

PI: Glen DuncanProject number: 2R56AG042176Project dates: 9/30/2017–8/31/2018 The overall goal of this research is to determine how the built environment (BE) in which individuals live, work, and play in on a daily basis influences their health. This proposal will continue a productive line of research into associations among the BE and health in a community-based sample of […]

Validation and Application of Portable Particulate Device in the UW Twin Registry

PI: Edmund Seto (UW) and Glen Duncan (WSU)Project number: R33ES024715Project dates: 9/1/2017–8/31/2021 This research addresses the mission of the National Institutes of Environmental Health Sciences by increasing our understanding of how the environment influences human health through validation of a new wearable device that measures multiple environmental toxicants in real-time and space, called the Portable University of […]

Cross-sectional association between soda consumption and body mass index in a community-based sample of twins

Eney AE, Tsang S, Delaney JA, Turkheimer E, Duncan GE. Background Consumption of sugar-sweetened beverages, such as soda, have been shown to play an important role in weight gain. Although soda consumption has been associated with body mass index (BMI) in many studies, it has been difficult to ascertain a true causal relationship between soda […]