Horn EE

Neighborhood Deprivation Moderates Shared and Unique Environmental Influences on Hazardous Drinking: Findings from a Cross-Sectional Co-Twin Study

Rhew IC, Fleming CB, Tsang S, Horn E, Kosterman R, Duncan GE. Background There has been increased interest in the interplay of genetic and environmental factors in the development of problematic alcohol use, including socioeconomic conditions of the neighborhood. Using a co-twin design, we examined the extent to which contributions of genetic, shared environmental, and […]

Neighborhood deprivation and depression in adult twins: genetics and gene×environment interaction

Strachan E, Duncan G, Horn E, Turkheimer E. Background Depression is a significant problem and it is vital to understand its underlying causes and related policy implications. Neighborhood characteristics are implicated in depression but the nature of this association is unclear. Unobserved or unmeasured factors may confound the relationship. This study addresses confounding in a […]

Is Marriage a Buzzkill? A Twin Study of Marital Status and Alcohol Consumption

Dinescu D, Turkheimer E, Beam CR, Horn EE, Duncan G, Emery RE. Married adults have consistently been found to drink less than their single or divorced counterparts. This correlation may not be causal, however, as people nonrandomly “select” into marriage and into alcohol use. The current study uses a sample of 2,425 same-sex twin pairs […]

Socioeconomic modifiers of genetic and environmental influences on body mass index in adult twins

Dinescu D, Horn EE, Duncan G, Turkheimer E Objective Individual measures of socioeconomic status (SES) suppress genetic variance in body mass index (BMI). Our objective was to examine the influence of both individual-level (i.e., educational attainment, household income) and macrolevel (i.e., neighborhood socioeconomic advantage) SES indicators on genetic contributions to BMI. Method The study used […]

Sleep Duration and Area-Level Deprivation in Twins

Watson NF, Horn E, Duncan GE, Buchwald D, Vitiello MV, Turkheimer E Study Objectives We used quantitative genetic models to assess whether area-level deprivation as indicated by the Singh Index predicts shorter sleep duration and modifies its underlying genetic and environmental contributions. Methods Participants were 4,218 adult twin pairs (2,377 monozygotic and 1,841 dizygotic) from […]

Behavioral and Environmental Modification of the Genetic Influence on Body Mass Index: A Twin Study

Horn EE, Turkheimer E, Strachan E, Duncan GE Body mass index (BMI) has a strong genetic basis, with a heritability around 0.75, but is also influenced by numerous behavioral and environmental factors. Aspects of the built environment (e.g., environmental walkability) are hypothesized to influence obesity by directly affecting BMI, by facilitating or inhibiting behaviors such […]

Quasi-causal associations of physical activity and neighborhood walkability with body mass index: A twin study

Duncan GE, Cash SW, Horn EE, Turkheimer E Physical activity, neighborhood walkability, and body mass index (BMI, kg/m(2)) associations were tested using quasi-experimental twin methods. We hypothesized that physical activity and walkability were independently associated with BMI within twin pairs, controlling for genetic and environmental background shared between them. Data were from 6376 (64% female; 58% […]