Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Jelenkovic A, Sumathipala A, Christensen K, Hopper JL, Cozen W, Mack TM, Sung J, Duncan GE, Buchwald D, Harris JR, Goldberg JH, Kaprio J, Silventoinen K, et al. Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis […]

Is Marriage a Buzzkill? A Twin Study of Marital Status and Alcohol Consumption

Dinescu D, Turkheimer E, Beam CR, Horn EE, Duncan G, Emery RE. Married adults have consistently been found to drink less than their single or divorced counterparts. This correlation may not be causal, however, as people nonrandomly “select” into marriage and into alcohol use. The current study uses a sample of 2,425 same-sex twin pairs […]

Resilient Coping Moderates the Effect of Trauma Exposure on Depression

Sinclair VG, Wallston KA, Strachan E. Posttraumatic depression rates are increasing in the United States, and there is a great need to identify malleable factors that could moderate posttraumatic depression levels. The purpose of this study was to examine whether resilient coping moderates the effects of trauma exposure on depression, while controlling for neuroticism-an established […]

Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

Silventoinen K, Jelenkovic A, Busjahn A, Cozen W, Mack TM, Craig JM, Harden KP, Duncan GE, Buchwald D, Goldberg JH, Kaprio J, et al. Background Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives We analyzed […]

Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Jelenkovic A, Craig JM, Sumathipala A, Harden KP, Cozen W, Mack TM, Hopper JL, Duncan GE, Buchwald D, Sung J, Harris JR, Busjahn A, Goldberg JH, Kaprio J, Silventoinen K, et al. Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and […]

Effects of Anxiety on Caloric Intake and Satiety-Related Brain Activation in Women and Men

Mestre ZL, Melhorn SJ, Askren MK, Tyagi V, Gatenby C, Young L, Mehta S, Webb MF, Grabowski TJ, Schur EA. Objective To test the relationship of anxiety to caloric intake and food cue perception in women and men. Methods Fifty-five twins (26 complete, 3 incomplete pairs; 51% women) underwent 2 functional magnetic resonance imaging (fMRI) […]

Cross Sectional Association between Spatially Measured Walking Bouts and Neighborhood Walkability

Hwang LD, Hurvitz PM, Duncan GE Walking is the most popular choice of aerobic physical activity to improve health among U.S. adults. Physical characteristics of the home neighborhood can facilitate or hinder walking. The purpose of this study was to quantify neighborhood walking, using objective methods and to examine the association between counts of walking […]

Alterations in Connectivity on Functional Magnetic Resonance Imaging with Provocation of Lower Urinary Tract Symptoms: A MAPP Research Network Feasibility Study of Urological Chronic Pelvic Pain Syndromes

Kleinhans NM, Yang CC, Strachan ED, Buchwald DS, Maravilla KR Purpose Urological chronic pelvic pain syndromes have refractory bladder or pelvic pain as the dominant symptom. This has been attributed to changes in the central nervous system caused by a chronic barrage of noxious stimuli. We developed what is to our knowledge a novel challenge […]

Brain regulation of appetite in twins

Melhorn SJ, Mehta S, Kratz M, Tyagi V, Webb MF, Noonan CJ, Buchwald DS, Goldberg J, Maravilla KR, Grabowski TJ, Schur EA Background Neural responses to highly energetic food cues are robust and are suppressed by eating. It is not known if neural responsiveness to food cues is an inherited trait and possibly even one […]

Socioeconomic modifiers of genetic and environmental influences on body mass index in adult twins

Dinescu D, Horn EE, Duncan G, Turkheimer E Objective Individual measures of socioeconomic status (SES) suppress genetic variance in body mass index (BMI). Our objective was to examine the influence of both individual-level (i.e., educational attainment, household income) and macrolevel (i.e., neighborhood socioeconomic advantage) SES indicators on genetic contributions to BMI. Method The study used […]

Sleep Duration and Area-Level Deprivation in Twins

Watson NF, Horn E, Duncan GE, Buchwald D, Vitiello MV, Turkheimer E Study Objectives We used quantitative genetic models to assess whether area-level deprivation as indicated by the Singh Index predicts shorter sleep duration and modifies its underlying genetic and environmental contributions. Methods Participants were 4,218 adult twin pairs (2,377 monozygotic and 1,841 dizygotic) from […]

Familial Contributions to Self-Reported Sleep and Pain in Female Twins

Godfrey KM, Strachan E, Mostoufi S, Poeschla B, Succop A, Afari N The relationship between sleep quality and pain has been studied in populations with chronic pain and in nonclinical populations using experimental paradigms. Little is known about the familial contributions to this relationship. This study examines self-reported sleep quality and pain in a nonclinical […]