Ally Avery

Examination of Cross-Sectional Associations of Neighborhood Deprivation and Alcohol Outlet Density With Hazardous Drinking Using a Twin Design

Rhew IC, Kosterman R, Duncan GE, Mair C. Objective The purpose of this study was to examine whether neighborhood socioeconomic deprivation and alcohol outlet density are associated with hazardous drinking using a co-twin design to control for confounding because of genetic and shared environmental factors. Method The study sample included cross-sectional data from 1,996 same-sex […]

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What Twin Studies Tell Us About Brain Responses to Food Cues

Schur E, Carnell S. Purpose of Review Functional magnetic resonance imaging (fMRI) using visual food cues provides insight into brain regulation of appetite in humans. This review sought evidence for genetic determinants of these responses. Recent Findings Echoing behavioral studies of food cue responsiveness, twin study approaches detect significant inherited influences on brain response to […]

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts

Silventoinen K, Jelenkovic A, Hopper JL, Busjahn A, Cozen W, Mack TM, Sumathipala A, Harris JR, Goldberg JH, Harden KP, Duncan GE, Buchwald D, Turkheimer E, Kaprio J, et al. Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences […]

TWINStudy of Environment, Lifestyle Behaviors, and Health

PI: Glen DuncanProject number: 2R56AG042176Project dates: 9/30/2017–8/31/2018 The overall goal of this research is to determine how the built environment (BE) in which individuals live, work, and play in on a daily basis influences their health. This proposal will continue a productive line of research into associations among the BE and health in a community-based sample of […]

Validation and Application of Portable Particulate Device in the UW Twin Registry

PI: Edmund Seto (UW) and Glen Duncan (WSU)Project number: R33ES024715Project dates: 9/1/2017–8/31/2021 This research addresses the mission of the National Institutes of Environmental Health Sciences by increasing our understanding of how the environment influences human health through validation of a new wearable device that measures multiple environmental toxicants in real-time and space, called the Portable University of […]

Cross-sectional association between soda consumption and body mass index in a community-based sample of twins

Eney AE, Tsang S, Delaney JA, Turkheimer E, Duncan GE. Background Consumption of sugar-sweetened beverages, such as soda, have been shown to play an important role in weight gain. Although soda consumption has been associated with body mass index (BMI) in many studies, it has been difficult to ascertain a true causal relationship between soda […]

Why does the DOL ask about twins?

The Washington State Department of Licensing (DOL) is unique in that it encodes your last name, first and middle initial, and your date of birth in your driver’s license or identification card number. Based on this formula, twins have the potential to generate the same license number. These license numbers look like the following: LLLLLFMYYXmd […]

Differences in genetic and environmental variation in adult body mass index by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts

Silventoinen K, Jelenkovic A, Cozen W, Mack T, Sumathipala A, Christensen K, Busjahn A, Duncan GE, Buchwald D, Goldberg JH, Hopper JL, Sung J, Turkheimer E, Kaprio J, et al. Background  Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m2)], but factors modifying these variance components are poorly understood. […]

Trust is heritable, whereas distrust is not

Reimann M, Schilke O, Cook KS. Why do people distrust others in social exchange? To what degree, if at all, is distrust subject to genetic influences, and thus possibly heritable, and to what degree is it nurtured by families and immediate peers who encourage young people to be vigilant and suspicious of others? Answering these questions could provide fundamental clues […]

Genetic and Environment Influences on Sleep, Pain, and Depression Symptoms in a Community Sample of Twins

Gasperi M, Herbert M, Schur E, Buchwald D, Afari N. Objective We used quantitative genetic methods to evaluate whether sleep quality, pain, and depression symptoms share a common genetic diathesis, to estimate the genetic and environmental sources of covariance among these symptoms, and to test for possible causal relationships. Methods A community sample of 400 […]

Neighborhood walkability moderates the association between low back pain and physical activity: A co-twin control study

Zadro JR, Shirley D, Pinheiro MB, Bauman A, Duncan GE, Ferreira PH. The aim of this study was to investigate whether neighborhood walkability moderates the association between low back pain (LBP) and physical activity (PA), using a co-twin design to control for genetics and shared environmental factors. A cross-sectional analysis was performed on 10,228 twins […]

Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Bogl LH, Jelenkovic A, Christensen K, Cozen W, Mack TM, Duncan GE, Buchwald D, Hopper JL, Silventoinen K, Kaprio J, et al. Background The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric […]

Neighborhood deprivation and depression in adult twins: genetics and gene×environment interaction

Strachan E, Duncan G, Horn E, Turkheimer E. Background Depression is a significant problem and it is vital to understand its underlying causes and related policy implications. Neighborhood characteristics are implicated in depression but the nature of this association is unclear. Unobserved or unmeasured factors may confound the relationship. This study addresses confounding in a […]

Dexamethasone-suppressed Salivary Cortisol and Pain Sensitivity in Female Twins

Godfrey KM, Herbert M, Strachan E, Mostoufi S, Crofford LJ, Buchwald D, Poeschla B, Succop A, Afari N. Objectives Hypothalamic-pituitary-adrenal (HPA) axis dysregulation is associated with chronic pain. Studying pain sensitivity and the HPA axis could elucidate the role of stress in chronic pain development, which might be influenced by familial factors, including genes. Methods […]

A Twin Study on Perceived Stress, Depressive Symptoms, and Marriage

Beam CR, Dinescu D, Emery R, Turkheimer E. Marriage is associated with reductions in both perceived stress and depressive symptoms, two constructs found to be influenced by common genetic effects. A study of sibling twins was used to test whether marriage decreases the proportion of variance in depressive symptoms accounted for by genetic and environmental […]

Transcriptional Signatures of Sleep Duration Discordance in Monozygotic Twins

Watson NF, Buchwald D, Delrow JJ, Altemeier WA, Vitiello MV, Pack AI, Bamshad M, Noonan C, Gharib S. Habitual short sleep duration is associated with adverse metabolic, cardiovascular, and inflammatory effects. Co-twin study methodologies account for familial (e.g., genetics and shared environmental) confounding, allowing assessment of subtle environmental effects, such as the effect of habitual […]

Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Jelenkovic A, Sumathipala A, Christensen K, Hopper JL, Cozen W, Mack TM, Sung J, Duncan GE, Buchwald D, Harris JR, Goldberg JH, Kaprio J, Silventoinen K, et al. Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis […]

New Study Opportunity

A research group at the University of Washington is seeking identical twins ages 9 to 14 for an exciting new brain imaging study! Twins will have their brains scanned while they engage in computer coding tasks. Twin participants will receive a print out of their brain scan, and parents will receive a written assessment report […]

Is Marriage a Buzzkill? A Twin Study of Marital Status and Alcohol Consumption

Dinescu D, Turkheimer E, Beam CR, Horn EE, Duncan G, Emery RE. Married adults have consistently been found to drink less than their single or divorced counterparts. This correlation may not be causal, however, as people nonrandomly “select” into marriage and into alcohol use. The current study uses a sample of 2,425 same-sex twin pairs […]