This study seeks to understand how the environment influences our health by testing a new device that will measure toxins in the environment. These toxins include air pollution, noise, and allergens. This study includes 2 waves, with the potential for a third. For the first wave, twins will come to our office in downtown Seattle to […]
While identical twins are born with the same set of genes, their lifetime experiences (environment) may differ. These environmental differences may cause small changes in how their genes are regulated (turned on or off). Such changes are called epigenetic modifications. One type of epigenetic modification is called DNA methylation. This study is recruiting identical twin […]
Purpose: Urological chronic pelvic pain syndromes have refractory bladder or pelvic pain as the dominant symptom. This has been attributed to changes in the central nervous system caused by a chronic barrage of noxious stimuli. We developed what is to our knowledge a novel challenge protocol that induced bladder distention in study participants to reproduce pain […]
A full understanding of the mechanisms involved in chronic pain could make a significant difference in the quality of life of chronic pain patients, as well as healthcare costs and productivity. Previous clinical studies have found associations between pain conditions and levels of C-Reactive Protein (CRP), a general indicator of inflammation in the body. This […]
This study looked at the relationship between how much sleep a person gets and how it influences metabolism and measures of inflammation, both of which are related to obesity. Fifty five (55) MZ twin pairs were invited to participate in this study. A twin study was done because it is the ideal way to look at […]
Results of a previous pilot study about oral herpes in twins suggested that there are genetic factors in an infected person that strongly influence the reactivation (waking up) of the HSV-1 virus from a dormant (sleeping) state to cause cold sores. The purpose of this study was to understand how the genes of the host, […]
The goal of this study is to learn more about the regulation of appetite, in order to better understand how the central nervous system regulates appetite and food consumption. This study required both members of the twin pair to come to the University of Washington Medical Center together for one eight-hour visit. Blood samples were collected […]
A total of 99 female twin pairs (198 women) participated in this study to understand more about the causes and conditions associated with chronic widespread pain. This study examined perceptions of pain, factors related to sleep, hormones related to the body’s response to stress, and inflammatory markers that might affect sensitivity to pain. A twin […]
Scientists have recently discovered a number of hormones that control appetite and regulate weight. These hormones travel in the bloodstream and some of them change rapidly with every meal. They influence when we get hungry, how full we feel and probably even what foods taste good to us. The main purpose of this study was […]
Obesity increases the risk of many diseases, including diabetes, heart disease, and cancer. There is evidence that there may be a link between obesity and inflammation (irritation) in the body and the kinds of bacteria found in the gut. The goal of this study was to better understand how body weight in adults and the […]
There are big differences in how people respond to severe bacterial infection. The inflammatory response of white blood cells to harmful bacteria that invade the body may play an important role in determining how well a patient will be able to fight the infection. The purpose of this study was to better understand how genetic […]
This study explored the role of the built environment in supporting healthy lifestyles. The built environment is defined as human-made surroundings, such as buildings, streets, and transportation systems, which support or hinder human activity. Although this topic has gained increasing attention from many researchers over the last several years, the influence of the environment on behaviors […]
Oral herpes is a very common infection of the mouth area. It is caused by the herpes simplex virus type-1 (HSV-1). When they are first infected, some people have symptoms while others do not. After the first infection, the virus becomes dormant (goes to sleep) in nerve tissues in the face for life. Periodically the […]
Background: Neural responses to highly energetic food cues are robust and are suppressed by eating. It is not known if neural responsiveness to food cues is an inherited trait and possibly even one that mediates the genetic influences on body weight that have been previously observed. Objective: We investigated the inherited influence on brain responses to high-calorie […]
Objective: The relationship between sleep quality and pain has been studied in populations with chronic pain and in nonclinical populations using experimental paradigms. Little is known about the familial contributions to this relationship. This study examines self-reported sleep quality and pain in a nonclinical sample and to explore familial (i.e., shared genetic and common family environment) […]
This study is being conducted by Dr. Kari Nadeau, an allergist and immunologist at Stanford University, and Dr. Rebecca Bauer, a postdoctoral researcher in Dr. Nadeau’s laboratory. The purpose of this study is to better understand how exposure to tobacco smoke affects immunity and diseases of the immune system such as asthma. Researchers will assess […]
There are several possible explanations for this: Twin-to-twin transfusion syndrome can cause one twin to be born larger than the other. Sometimes in a twin pregnancy the placenta does not grow large enough to provide enough oxygen and nutrients to both fetuses. Or one fetus may just have implanted in a location within the womb […]
Twins share a special connection beyond that of ordinary siblings. Some people believe that this unique twin bond is endowed with extraordinary supernatural qualities. There are many stories that support this idea. For example, twins will report that one twin experienced a physical sensation of something that was happening to their twin, such as a […]
Mirror image twins are a type of identical (monozygotic or MZ) twins. The term “mirror image” is used because the twins, when facing each other, appear as matching reflections. They have the same physical features but some are opposite. For example, if one twin is right-handed the other twin may be left-handed. Their hair whorls […]
Yes! Twins are defined as children produced in the same pregnancy. Usually they are delivered only a few minutes or hours apart. But they can have different birthdays. This most commonly happens when labor and delivery begins before midnight on one day and ends after the clock changes to the next day. If that day […]
