asthma

Transcriptomic and methylomic features in asthmatic and non-asthmatic twins

Asthma is the most prevalent chronic lung inflammatory disorder characterized by reversible airflow obstruction, affecting 358 million people worldwide, with aggravating factors like obesity, attention‐deficit/hyperactivity disorder, socioeconomic status like poor healthcare affordability and facility, smoking and alcohol intake. RNA sequencing (RNA‐seq) in atopic asthma, childhood asthma and adult‐onset severe asthma has improved our understanding of cellular and […]

Genetic pleiotropy between asthma and obesity in a community-based sample of twins

Background: Asthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic or environmental causes. Objective: We sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared genetic cause. Methods: The analyses were performed with 1001 monozygotic […]