Zhao J

Zhu Y, Strachan E, Fowler E, Bacus T, Roy-Byrne P, Zhao J. DNA methylation plays an important role in major depressive disorder (MDD), but the specific genes and genomic regions associated with MDD remain largely unknown. Here we conducted genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) and gene expression (RNA-seq) in peripheral blood monocytes […]

Strachan E, Zhao J, Roy-Byrne PP, Fowler E, Bacus T. Major depression is a complex disorder with no single, direct causal mechanism. Morbidity has been linked to genetic processes, developmental history, and unique environmental exposures. Epigenetic mechanisms, especially DNA methylation, are also likely important factors in the pathogenesis of major depressive disorder (MDD). A community-based […]

Peng H, Zhu Y, Strachan E, Fowler E, Bacus T, Roy-Byrne P, Goldberg J, Vaccarino V, Zhao J. Objective DNA methylation has been associated with both early life stress and depression. This study examined the combined association of DNA methylation at multiple CpG probes in five stress-related genes with depressive symptoms, and tested whether these […]

PI: Jinying Zhao and Eric StrachanProject number: 5R01MH097018Project dates: 8/15/2013–7/31/2018 Major depressive disorder (MDD) is a devastating psychiatric disorder that affects millions of Americans. Despite substantial research, no specific risk factor has yet been identified as having a causal role in MDD. Epigenetic modifications, especially DNA methylation, are increasingly being recognized as a key mechanism involved in […]