Webb M

Reassessing relationships between appetite and adiposity in people at risk of obesity: a twin study using fMRI

Sewaybricker LE, Melhorn SJ, Rosenbaum JL, Askren MK, Tyagi V, Webb MF, De Leon MRB, Grabowski TJ, Schur EA Background Neuroimaging studies suggest that appetitive drive is enhanced in obesity. Objective To test if appetitive drive varies in direct proportion to the level of body adiposity after accounting for genetic factors that contribute to both […]

Salience network connectivity is reduced by a meal and influenced by genetic background and hypothalamic gliosis

Sewaybricker LE, Melhorn SJ, Askren MK, Webb MF, Tyagi V, De Leon MRB, Grabowski TJ, Seeley WW, Schur EA. BACKGROUND/OBJECTIVES The salience network (SN) comprises brain regions that evaluate cues in the external environment in light of internal signals. We examined the SN response to meal intake and potential genetic and acquired influences on SN […]

Hypothalamic Gliosis by MRI and Visceral Fat Mass Negatively Correlate with Plasma Testosterone Concentrations in Healthy Men

Berkseth KE, Rubinow KB, Melhorn SJ, Webb MF, De Leon MRB, Marck BT, Matsumoto AM, Amory JK, Page ST, Schur EA. Objective This study aimed to determine whether a relationship was evident between gliosis in the mediobasal hypothalamus (MBH) and plasma testosterone concentrations in men. Methods A total of 41 adult men (aged 18-50 years) […]

Effects of Anxiety on Caloric Intake and Satiety-Related Brain Activation in Women and Men

Mestre ZL, Melhorn SJ, Askren MK, Tyagi V, Gatenby C, Young L, Mehta S, Webb MF, Grabowski TJ, Schur EA. Objective To test the relationship of anxiety to caloric intake and food cue perception in women and men. Methods Fifty-five twins (26 complete, 3 incomplete pairs; 51% women) underwent 2 functional magnetic resonance imaging (fMRI) […]

Brain regulation of appetite in twins

Melhorn SJ, Mehta S, Kratz M, Tyagi V, Webb MF, Noonan CJ, Buchwald DS, Goldberg J, Maravilla KR, Grabowski TJ, Schur EA Background Neural responses to highly energetic food cues are robust and are suppressed by eating. It is not known if neural responsiveness to food cues is an inherited trait and possibly even one […]

In adult twins, visceral fat accumulation depends more on exceeding sex-specific adiposity thresholds than on genetics

Bosch TA, Chow L, Dengel DR, Melhorn SJ, Webb M, Yancey D, Callahan H, De Leon MRB, Tyagi V, Schur EA We recently reported sex-specific percent body fat (%BF) thresholds (males = 23%, females = 38%) above which, visceral adipose tissue (VAT) significantly increases. Using monozygotic (MZ) and dizygotic (DZ) twins, we examined the influence of genetics on regional […]