Grabowski TJ

Reassessing relationships between appetite and adiposity in people at risk of obesity: a twin study using fMRI

Sewaybricker LE, Melhorn SJ, Rosenbaum JL, Askren MK, Tyagi V, Webb MF, De Leon MRB, Grabowski TJ, Schur EA Background Neuroimaging studies suggest that appetitive drive is enhanced in obesity. Objective To test if appetitive drive varies in direct proportion to the level of body adiposity after accounting for genetic factors that contribute to both […]

Salience network connectivity is reduced by a meal and influenced by genetic background and hypothalamic gliosis

Sewaybricker LE, Melhorn SJ, Askren MK, Webb MF, Tyagi V, De Leon MRB, Grabowski TJ, Seeley WW, Schur EA. BACKGROUND/OBJECTIVES The salience network (SN) comprises brain regions that evaluate cues in the external environment in light of internal signals. We examined the SN response to meal intake and potential genetic and acquired influences on SN […]

Effects of Anxiety on Caloric Intake and Satiety-Related Brain Activation in Women and Men

Mestre ZL, Melhorn SJ, Askren MK, Tyagi V, Gatenby C, Young L, Mehta S, Webb MF, Grabowski TJ, Schur EA. Objective To test the relationship of anxiety to caloric intake and food cue perception in women and men. Methods Fifty-five twins (26 complete, 3 incomplete pairs; 51% women) underwent 2 functional magnetic resonance imaging (fMRI) […]

Brain regulation of appetite in twins

Melhorn SJ, Mehta S, Kratz M, Tyagi V, Webb MF, Noonan CJ, Buchwald DS, Goldberg J, Maravilla KR, Grabowski TJ, Schur EA Background Neural responses to highly energetic food cues are robust and are suppressed by eating. It is not known if neural responsiveness to food cues is an inherited trait and possibly even one […]