2020

Association Between Low Back Pain and Body Mass Index in Adult Twins: An analysis of monozygotic and dizygotic twins of the Washington State Twin Registry

Liechty A, Tsang S, Turkheimer E, Duncan GE. Background Context LBP is a common and significant cause of disability worldwide, however; questions about cause still remain. Purpose To investigate the association between low back pain (LBP), body mass index (BMI), and moderate to vigorous physical activity (MVPA) in a twin sample. Study Design Cross sectional […]

Stress, Anxiety, and Change in Alcohol Use During the COVID-19 Pandemic: Findings Among Adult Twin Pairs

Avery AR, Tsang S, Seto EYW, Duncan GE. The novel coronavirus (COVID-19) has impacted the lives of people worldwide since being declared a pandemic on March 11, 2020. Social restrictions aimed at flattening the curve may be associated with an increase in stress and anxiety, which may increase the use of alcohol as a coping […]

Central and Peripheral Symptoms in Network Analysis are Differentially Heritable A Twin Study of Anxious Misery

Olatunji BO, Christian C, Strachan E, Levinson CA. Background Evidence suggests that depression and anxiety disorders are genetically based. Although symptoms of these internalizing disorders tend to correlate, the degree to which the related symptoms are heritable is unclear. This overlap has been conceptualized as Anxious Misery and existing research examining similar constructs of negative […]

Perceived change in physical activity levels and mental health during COVID-19: Findings among adult twin pairs

Duncan GE, Avery AR, Seto E, Tsang S Background Physical distancing and other COVID-19 pandemic mitigation strategies may have unintended consequences on a number of health behaviors and health outcomes. The purpose of this study was to investigate the association between perceived change in physical activity or exercise and mental health outcomes over the short-term […]

Psychometric and Classification Properties of the Peas in a Pod Questionnaire

Avery AR, Turkheimer E, Tsang S, Duncan GE We examined the item properties of the Two Peas Questionnaire (TPQ) among a sample of same-sex twin pairs from the Washington State Twin Registry. With the exception of the ‘two peas’ item, three of the mistakenness items showed differential item functioning. Results showed that the monozygotic (MZ) […]

Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts

Silventoinen K, Jelenkovic A, Sund R, et al. We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or […]

Associations between changes in resilient coping and posttraumatic stress disorder symptoms

Sinclair VG, Adams SM, Dietrich M. The pervasive, damaging nature of posttraumatic stress disorder (PTSD) presents enormous clinical challenges. Understanding the relationship between patients’ perceptions of PTSD symptoms and resilient coping strategies may prompt investigation of clinical interventions that improve adaptive, resilient coping skills. In this study, we examined whether changes in resilient coping were […]

Heritability of affectionate communication: A twins study

Floyd K, York C, Ray CD. Using a twin study design, we explored the extent to which affectionate communication is a heritable behavioral trait. Participants (N = 928) were 464 adult twin pairs (229 monozygotic, 235 dizygotic) who provided data on their affectionate communication behaviors. Through ACE modeling, we determined that approximately 45% of the variance in trait expressed […]

Neighborhood Deprivation Moderates Shared and Unique Environmental Influences on Hazardous Drinking: Findings from a Cross-Sectional Co-Twin Study

Rhew IC, Fleming CB, Tsang S, Horn E, Kosterman R, Duncan GE. Background There has been increased interest in the interplay of genetic and environmental factors in the development of problematic alcohol use, including socioeconomic conditions of the neighborhood. Using a co-twin design, we examined the extent to which contributions of genetic, shared environmental, and […]

Transcriptomic and methylomic features in asthmatic and non-asthmatic twins

Dhondalay GKR, Bunning B, Bauer RN, Barnathan ES, Maniscalco C, Baribaud F, Nadeau KC, Andorf S. Asthma is the most prevalent chronic lung inflammatory disorder characterized by reversible airflow obstruction, affecting 358 million people worldwide, with aggravating factors like obesity, attention‐deficit/hyperactivity disorder, socioeconomic status like poor healthcare affordability and facility, smoking and alcohol intake. RNA sequencing […]

Insomnia and posttraumatic stress symptoms: Evidence of shared etiology

Cox RC, Taylor S, Strachan E, Olatunji BO. Posttraumatic stress disorder (PTSD) and insomnia are comorbid clinical conditions that are thought to result from genetic and environmental effects. Though studies have established the heritability of these disorders independently, no study to date has examined the genetic contributions to the relation between insomnia and PTSD symptoms […]

The Effect of Twin Sex on Menstrual Characteristics

Kowynia E, Jahanfar S. Background and objectives The purpose of this project is to evaluate the association between twin sex discordance and menstrual characteristics. We hypothesize that sharing the uterus with a male twin can change ovulation programming, hence changing the menstrual cycle characteristics during adulthood. This project could be novel in discovering new physiological […]